Patent Number: 8,796,246

Title: 9, 10-secopregnane derivative and pharmaceutical

Abstract: A main object of the invention is to provide a novel useful vitamin D.sub.3 derivative, which has an excellent vitamin D.sub.3 activity and, as compared with conventional vitamin D.sub.3 derivatives, has a relatively small amount of influence on the systemic calcium metabolism. The invention includes a 9,10-secopregnane derivative of the following general formula [1] and a pharmaceutical composition containing it as active ingredient. ##STR00001## In the general formula [1], the following partial structure between the 16-position and the 17-position means a single bond or a double bond: ##STR00002## Y is a single bond, an alkylene, an alkenylene or phenylene; R.sup.1 and R.sup.2 are the same or different, each represents hydrogen, an alkyl or a cycloalkyl; or R.sup.1 and R.sup.2, taken together with the adjacent carbon atom, form a cycloalkyl; R.sup.3 is hydrogen or methyl; Z is hydrogen, hydroxy or --NR.sup.11R.sup.12.

Inventors: Fujieda; Hiroki (Kobe, JP), Otsu; Hironori (Matsubara, JP), Yasufuku; Shoji (Otsu, JP), Shirai; Masaaki (Kyoto, JP)

Assignee: Nippon Shinyaku Co., Ltd.

International Classification: A61K 31/593 (20060101); C07C 401/00 (20060101)

Expiration Date: 8/05/12018