Patent Number: 8,796,280

Title: 2,3-disubstituted pyrazinesulfonamides as CRTH2 inhibitors

Abstract: The present invention is related to the use of 2,3 substituted pyrazine sulfonamides of formula (I) ##STR00001## for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is related to the use of 2,3 substituted pyrazine sulfonamides for the modulation, notably the inhibition, of CRTH2 activity.

Inventors: Page; Patrick (Saint-Julien-en-Genevois, FR), Schwarz; Matthias (Gland, CH), Sebille; Eric (Le Poizat, FR), Cleva; Christophe (La Tour, FR), Merlot; Cedric (Collonges-sous-Saleve, FR), Maio; Maurizio (Renens, CH)

Assignee: Merck Serono, S.A.

International Classification: A61K 31/4965 (20060101)

Expiration Date: 8/05/12018