Patent Number: 8,796,295

Title: Substituted benzamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same

Abstract: Disclosed are negative allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating neurological and psychiatric disorders associated with glutamate dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Inventors: Conn; P. Jeffrey (Brentwood, TN), Lindsley; Craig W. (Brentwood, TN), Emmitte; Kyle A. (Spring Hill, TN), Weaver; Charles David (Franklin, TN), Rodriguez; Alice L. (Nashville, TN), Felts; Andrew S. (Nashville, TN), Jones; Carrie K. (Nashville, TN), Bates; Brittney S. (Nashville, TN)

Assignee: Vanderbilt University

International Classification: A61K 31/505 (20060101); A61K 31/44 (20060101); C07D 417/12 (20060101); C07D 239/02 (20060101)

Expiration Date: 8/05/12018