Patent Number: 8,815,503

Title: Compositions and methods for immunostimulatory RNA oligonucleotides

Abstract: The present invention provides 4-nucleotide (4mer) RNA motifs that confer immunostimulatory activity, in particular, IL-12-inducing activity to a single-stranded RNA oligonucleotide. The present invention also provides single-stranded RNA oligonucleotides, including antisense RNA, with high or low immunostimulatory activity. The present invention further provides the use of the RNA oligonucleotides of the invention for therapeutic purposes.

Inventors: Hartmann; Gunther (Bonn, DE), Hornung; Veit (Pullach, DE)

Assignee: Rheinische Friedrich-Wilhelms-Universitat Bonn

International Classification: C12Q 1/68 (20060101); C07H 21/02 (20060101); C07H 21/04 (20060101)

Expiration Date: 8/26/12018