Patent Number: 8,815,809

Title: Cysteine protease inhibitors

Abstract: Compounds of Formula II ##STR00001## wherein R.sup.1a is H; and R.sup.1b is C.sub.1-C.sub.6alkyl, Carbocyclyl or Het; or R.sup.1a and R.sup.1b together define a saturated cyclic amine with 3-6 ring atoms; R.sup.2a and R.sup.2b are independently H, halo, C.sub.1-C.sub.4alkyl, C.sub.1-C.sub.4haloalkyl or C.sub.1-C.sub.4alkoxy, or R.sup.2a and R.sup.2b together with the carbon atom to which they are attached form a C.sub.3-C.sub.6cycloalkyl; R.sup.3 is a branched C.sub.5-C.sub.10 alkyl chain, C.sub.2-C.sub.4haloalkyl or --CH.sub.2C.sub.3-C.sub.7 cycloalkyl; R.sup.4' is C.sub.1-C.sub.6alkyl, C.sub.1-C.sub.6haloalkyl or oxetany-3-yl. for use in the prophylaxis or treatment of a disorder characterized by inappropriate expression or activation of cathepsin S.

Inventors: Ayesa; Susana (Huddinge, SE), Ersmark; Karolina (Huddinge, SE), Grabowska; Urszula (Huddinge, SE), Hewitt; Ellen (Huddinge, SE), Jonsson; Daniel (Huddinge, SE), Kahnberg; Pia (Huddinge, SE), Klasson; Bjorn (Huddinge, SE), Lind; Peter (Huddinge, SE), Lundgren; Stina (Huddinge, SE), Oden; Lourdes (Huddinge, SE), Parkes; Kevin (Huddinge, SE), Wiktelius; Daniel (Huddinge, SE)

Assignee: Medivir UK Ltd

International Classification: A61K 38/00 (20060101); A61K 38/05 (20060101)

Expiration Date: 8/26/12018