Patent Number: 8,815,841

Title: 1,4-Oxazepines as BACE1 and/or BACE2 inhibitors

Abstract: This invention relates to compounds of the formula ##STR00001## wherein and R.sup.1 to R.sup.3 are as described herein, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as pharmaceuticals for the therapeutic and/or prophylactic treatment of diseases such as Alzheimer's disease, diabetes, particularly type 2 diabetes, and other metabolic disorders.

Inventors: Hilpert; Hans (Muenchenstein, CH), Narquizian; Robert (Zaessingue, FR)

Assignee: Hoffmann-La Roche Inc.

International Classification: A61K 31/553 (20060101)

Expiration Date: 8/26/12018