Patent Number: 8,815,844

Title: Mitochondrial activity inhibitors of cancer-initiating cells and use thereof

Abstract: The present invention relates to the compounds useful in the prevention and/or treatment of tumors. More specifically the present invention relates to inhibitors of the activity of the electron transport chains and/or the mitochondrial TCA cycle in glioma-initiating cells (GICs) for use in a method for preventing and/or treating tumors presenting glioma-initiating cells (GICs) in a subject who has undergone a prior removal of a tumor glioma bulk. The present invention further provides a pharmaceutical composition containing the inhibitors of the invention and a screening method for identifying the inhibitors of the invention.

Inventors: Clement; Virginie (Ferney-Voltaire, FR), Radovanovic; Ivan (Geneva, CH)

Assignee: Universite de Geneve

International Classification: A61K 31/55 (20060101); C07D 321/00 (20060101)

Expiration Date: 8/26/12018