Patent Number: 8,815,877

Title: Serine/threonine kinase inhibitors

Abstract: Compounds having the formula I wherein A, R.sup.1a, R.sup.1b, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, R.sup.8, R.sup.a, R.sup.b, X.sup.1, X.sup.2, X.sup.3 and n are as defined herein are inhibitors of PAK1. Also disclosed are compositions and methods for treating cancer and hyperproliferative disorders. ##STR00001##

Inventors: Aliagas-Martin; Ignacio (San Francisco, CA), Crawford; James (South San Francisco, CA), Lee; Wendy (San Ramon, CA), Mathieu; Simon (San Francisco, CA), Rudolph; Joachim (Burlingame, CA)

Assignee: Genentech, Inc.

International Classification: C07D 403/12 (20060101); A61K 31/505 (20060101)

Expiration Date: 8/26/12018