Patent Number: 8,815,951

Title: Inhibitors of epoxide hydrolases for the treatment of inflammation

Abstract: The invention provides compounds that inhibit epoxide hydrolase in therapeutic applications for treating hypertension. A preferred class of compounds for practicing the invention have the structure shown by Formula 1 ##STR00001## wherein Z is oxygen or sulfur, W is carbon phosphorous or sulfur, X and Y is each independently nitrogen, oxygen, or sulfur, and X can further be carbon, at least one of R.sub.1-R.sub.4 is hydrogen, R.sub.2 is hydrogen when X is nitrogen but is not present when X is sulfur or oxygen, R.sub.4 is hydrogen when Y is nitrogen but is not present when Y is sulfur or oxygen, R.sub.1 and R.sub.3 is each independently C.sub.1-C.sub.20 substituted or unsubstituted alkyl, cycloalkyl, aryl, acyl, or heterocyclic.

Inventors: Hammock; Bruce D (Davis, CA), Zheng; Jiang (Seattle, WA), Morisseau; Christophe (Davis, CA), Motoba; Kazuhiko (Kawachinagano, JP), Moghaddam; Mehran F. (San Diego, CA), Borhan; Babak (East Lansing, MI), Grant; David F. (Storrs, CT), Greene; Jessica (Oakland, CA), Sisemore; Marlene F. (Davis, CA), Sanborn; James (Sacramento, CA)

Assignee: The Regents of the University of California

International Classification: A01N 47/28 (20060101); A61K 31/17 (20060101)

Expiration Date: 8/26/12018