Patent Number: 8,816,072

Title: Process for the preparation of crystalline aprepitant having form I content

Abstract: The present invention provides a process for preparation of crystalline aprepitant having not more than 15% by weight of Form I content which comprises, a) dissolving aprepitant in a suitable solvent to obtain a solution, b) cooling the solution to 10-15.degree. C., c) optionally seeding the solution with aprepitant Form I crystals, d) adding an anti-solvent to the solution, and e) isolating crystalline aprepitant having not more than 15% by weight of Form I content.

Inventors: Jain; Deepak Mohanlal (Surat, IN), Khurana; Maneck (New Delhi, IN), Mehta; Hiten Sharadchandra (Ahmedabad, IN), Tatiya; Abhay (Aurangabad, IN), Nath; Asok (Gurgaon, IN), Gade; Sanjay Mahadeo (Solapur, IN), Prasad; Mohan (Gurgaon, IN), Dhar; Subhash (New Delhi, IN)

Assignee: Ranbaxy Laboratories Limited

International Classification: C07D 413/06 (20060101)

Expiration Date: 8/26/12018