Patent Number: 8,821,937

Title: Methods of treating cardiovascular disorders associated with atherosclerosis

Abstract: Layered phyllosilicates are useful for adsorbing and/or binding to cholesterol and, thereby, reducing blood cholesterol in a patient. Accordingly, provided herein is a method of reducing hypercholesteremia in a mammal comprising administering to the mammal a protonated and at least partially exfoliated layered phyllosilicate material alone and in combination with other cholesterol-reducing agents in an amount effective to reduce hypercholesteremia in the mammal. Also provided are methods of treating a cardiovascular disorder associated with atherosclerosis in a mammalian subject comprising administering to the subject a layered phyllosilicate material in an amount effective to reduce atherosclerotic lesion formation in the subject.

Inventors: Darlington, Jr.; Jerald W. (Marengo, IL)

Assignee: Amcol International Corporation

International Classification: A61K 9/14 (20060101); A61K 33/00 (20060101); A01N 59/00 (20060101)

Expiration Date: 9/02/12018