Patent Number: 8,822,179

Title: Nucleic acid compositions and the encoding proteins

Abstract: The subject invention provides at least one nucleic acid sequence encoding an aldouronate-utilization regulon isolated from Paenibacillus sp. strain JDR-2, a bacterium which efficiently utilizes xylan and metabolizes aldouronates (methylglucuronoxylosaccharides). The subject invention also provides a means for providing a coordinately regulated process in which xylan depolymerization and product assimilation are coupled in Paenibacillus sp. strain JDR-2 to provide a favorable system for the conversion of lignocellulosic biomass to biobased products. Additionally, the nucleic acid sequences encoding the aldouronate-utilization regulon can be used to transform other bacteria to form organisms capable of producing a desired product (e.g., ethanol, 1-butanol, acetoin, 2,3-butanediol, 1,3-propanediol, succinate, lactate, acetate, malate or alanine) from lignocellulosic biomass.

Inventors: Preston, III; James F. (Micanopy, FL), Chow; Virginia (Gainesville, FL), Nong; Guang (Gainesville, FL), Rice; John D. (Gainesville, FL), St. John; Franz J. (Baltimore, MD)

Assignee: University of Florida Research Foundation, Inc.

International Classification: A61K 38/00 (20060101)

Expiration Date: 9/02/12018