Patent Number: 8,822,407

Title: Preparation of conjugates comprising adenine derivatives and allergenic proteins and their use for specific immunotherapy of allengenic diseases

Abstract: The present invention refers to the preparation of adenine derivative active esters of formula (I) and use thereof for the preparation of stable conjugates between adenine derivative and allergenic proteins having general structure (II) for the modulation of T.sub.H2 response in allergic diseases. (I, II). ##STR00001##

Inventors: Romagnani; Sergio (Florence, IT), Maggi; Enrico (Florence, IT), Parronchi; Paola (Florence, IT), Guarna; Antonio (Seravezza, IT), Occhiato; Ernesto Giovanni (Florence, IT)

Assignee: Universita' Degli Studi di Firenze

International Classification: A61K 38/00 (20060101)

Expiration Date: 9/02/12018