Patent Number: 8,822,453

Title: Nitrogen-containing compounds and pharmaceutical compositions thereof for the treatment of atrial fibrillation

Abstract: The present invention provides a novel diazepine compound that blocks the I.sub.Kur current or the Kv1.5 channel potently and more selectively than other K.sup.+ channels. The present invention relates to a diazepine compound represented by General Formula (1) ##STR00001## or a salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are each independently hydrogen, lower alkyl, cyclo lower alkyl or lower alkoxy lower alkyl; R.sup.2 and R.sup.3 may be linked to form lower alkylene; A.sup.1 is lower alkylene optionally substituted with one or more substituents selected from the group consisting of hydroxyl and oxo; Y.sup.1 and Y.sup.2 are each independently --N.dbd. or --CH.dbd.; and R.sup.5 is group represented by ##STR00002## wherein R.sup.6 and R.sup.7 are each independently hydrogen or organic group; R.sup.6 and R.sup.7 may be linked to form a ring together with the neighboring group --X.sub.A--N--X.sub.B--; X.sub.A and X.sub.B are each independently a bond, lower alkylene, etc.

Inventors: Matsumura; Shuuji (Osaka, JP), Yamabe; Hokuto (Osaka, JP), Isono; Naohiro (Osaka, JP), Takemura; Noriaki (Osaka, JP), Oshiyama; Takashi (Osaka, JP), Nagase; Tsuyoshi (Osaka, JP), Ueda; Masataka (Osaka, JP), Tai; Kuninori (Osaka, JP)

Assignee: Otsuka Pharmaceutical Co., Ltd.

International Classification: C07D 243/12 (20060101); A61K 31/551 (20060101); A61P 9/06 (20060101); A61K 31/4985 (20060101); C07D 495/04 (20060101); C07D 409/12 (20060101)

Expiration Date: 9/02/12018