Patent Number: 8,822,456

Title: Hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds

Abstract: The present invention provides compounds of Formula I, and the tautomers thereof, and the pharmaceutically acceptable salts of the compounds and tautomers, wherein the compounds have the structure ##STR00001## wherein the variables R.sup.1, R.sup.2, R.sup.3, R.sup.4 and x are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Inventors: Brodney; Michael Aaron (Newton, MA), Beck; Elizabeth Mary (Cambridge, MA), Butler; Christopher Ryan (Canton, MA), Davoren; Jennifer Elizabeth (Cambridge, MA), O'Neill; Brian Thomas (Haddam, CT)

Assignee: Pfizer Inc.

International Classification: C07D 513/04 (20060101); A61K 31/542 (20060101)

Expiration Date: 9/02/12018