Patent Number: 8,822,514

Title: Multi-cyclic compounds and methods of use

Abstract: The present invention relates to compounds of Formulas I and II, ##STR00001## wherein B.sup.1, B.sup.2, B.sup.3, B.sup.4, C.sup.1, C.sup.2, ring D, L.sup.1, L.sup.2 and R.sup.1-4 are defined herein, synthetic intermediates, and pharmaceutical compositions, comprising such compounds. The compounds and compositions are capable of modulating various protein kinase receptors such as Tie-2 and Aurora and, therefore, influencing kinase related disease states and conditions. The compounds, for example, are capable of treating cancer caused by unregulated angiogenesis, and inflammation as well as other proliferative disorders.

Inventors: Hodous; Brian L. (Cambridge, MA), Geuns-Meyer; Stephanie D. (Medford, MA), Olivieri; Philip R. (Charlestown, MA), Patel; Vinod F. (Acton, MA), Tempest; Paul A. (Brookline, MA)

Assignee: Amgen Inc.

International Classification: A61K 31/421 (20060101); C07D 263/32 (20060101)

Expiration Date: 9/02/12018