Patent Number: 8,822,674

Title: Crystal form of 4-isopropylphenyl glucitol compound and process for production thereof

Abstract: A highly stable crystal of (1S)-1,5-anhydro-1-[5-(4-{(1E)-4-[(1-{[2-(dimethylamino)ethyl]amino}-2-me- thyl-1-oxopropan-2-yl)amino]-3,3-dimethyl-4-oxobut-1-en-1-yl}benzyl)-2-met- hoxy-4-(propan-2-yl)phenyl]-D-glucitol, and a process for producing the crystal are provided. Specifically, an ethanolate having the following physical properties, and a plurality of other crystal forms transformed from the ethanolate are provided: (a) Having peaks at 2.theta.=5.9 degrees, 17.1 degrees, 17.6 degrees and 21.5 degrees in X-ray powder diffraction (Cu--K.alpha.); (b) Showing characteristic absorption bands at 3538 cm.sup.-1, 3357 cm.sup.-1, 2964 cm.sup.-1, 1673 cm.sup.-1, 1634 cm.sup.-1 and 1505 cm.sup.-1 in an infrared absorption spectrum; and (c) Having a melting point in a vicinity of 111.degree. C.

Inventors: Kimura; Yoshihiro (Toshima-ku, JP), Imura; Koreaki (Toshima-ku, JP), Osaki; Naoto (Toshima-ku, JP), Matsushima; Ayumi (Toshima-ku, JP)

Assignee: Taisho Pharmaceutical Co., Ltd

International Classification: C07H 7/04 (20060101)

Expiration Date: 9/02/12018