Patent Number: 8,871,205

Title: Methods and compositions for the treatment of immune disorders

Abstract: The present invention provides a method of treating an immune-related disorder in a subject, comprising administering to the subject an effective amount of an inhibitor of plexin-A4 activity, which results in reducing the plexin-A4 activity in the subject, and thereby treating the immune-related disorder. Inhibitors of plexin-A4 activity include, for example, plexin-A4 antibodies and plexin-A4 fusion proteins. The present invention further provides a method of treating an immune-related disorder in a subject, comprising administering to the subject an effective amount of an inhibitor of semaphorin-3A (Sema3A) activity, which results in reducing the Sema3A activity in the subject, thereby treating the immune-related disorder. Inhibitors of Sema3A activity include, for example, Sema3A antibodies and Sema3A fusion proteins.

Inventors: Ting; Jenny P.-Y. (Chapel Hill, NC), Wen; Haitao (Carrboro, NC)

Assignee: The University of North Carolina at Chapel Hill

International Classification: A61K 39/395 (20060101)

Expiration Date: 2018-10-28 0:00:00