Patent Number: 8,871,456

Title: Probe incorporation mediated by enzymes

Abstract: The invention provides compositions and methods of use thereof for labeling peptide and proteins in vitro or in vivo. The methods described herein employ lipoic acid ligase or mutants thereof, and lipoic acid analogs recognized by lipoic acid ligase and lipoic acid ligase mutants.

Inventors: Ting; Alice Y. (Allston, MA), Suarez; Marta Fernandez (Cambridge, MA), Baruah; Hemanta (Cambridge, MA)

Assignee: Massachusetts Institute of Technology

International Classification: G01N 33/53 (20060101); A61K 38/00 (20060101); C12N 9/12 (20060101); C07H 21/04 (20060101)

Expiration Date: 2018-10-28 0:00:00