Patent Number: 8,871,734

Title: Transgene delivering retrovirus targeting collagen exposed at site of tissue injury

Abstract: A viral or non-viral vector particle having a modified viral surface protein wherein the viral surface protein is modified to include a targeting polypeptide including a binding region which binds to an extracellular matrix component. Such vector particles are useful in delivering genes encoding therapeutic agents to cells located at the site of an exposed extracellular matrix component.

Inventors: Hall; Frederick L. (Glendale, CA), Gordon; Erilinda Maria (Glendale, CA)

Assignee: The University of Southern California

International Classification: C07H 21/04 (20060101); A61K 48/00 (20060101)

Expiration Date: 2018-10-28 0:00:00