Patent Number: 8,871,760

Title: [1,2,4]triazolo[3,4-C][1,4]oxazines as P2X7 modulators

Abstract: Compounds of the formula I: ##STR00001## or pharmaceutically acceptable salts thereof, wherein X, Y, R.sup.1, R.sup.2, and R.sup.3 are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

Inventors: Brotherton-Pleiss; Christine E. (Sunnyvale, CA), Harris, III; Ralph New (Redwood City, CA), Loe; Bradley E. (Santa Cruz, CA), Lopez-Tapia; Francisco Javier (Mahwah, NJ), Rege; Pankaj D. (Hoboken, NJ), Repke; David Bruce (Milpitas, CA), Stabler; Russell Stephen (Boulder Creek, CA), Walker; Keith Adrian Murray (Los Altos Hills, CA)

Assignee: Roche Palo Alto LLC

International Classification: A61K 31/5383 (20060101); C07D 498/04 (20060101)

Expiration Date: 2018-10-28 0:00:00