Patent Number: 8,871,774

Title: Inhibitors of influenza viruses replication

Abstract: Methods of inhibiting the replication of influenza viruses in a biological sample or patient, of reducing the amount of influenza viruses in a biological sample or patient, and of treating influenza in a patient, comprises administering to said biological sample or patient an effective amount of a compound represented by Structural Formula (I): ##STR00001## or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A compound is represented by Structural Formula (I) or a pharmaceutically acceptable salt thereof, wherein the values of Structural Formula (I) are as described herein. A pharmaceutical composition comprises an effective amount of such a compound or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, adjuvant or vehicle.

Inventors: Charifson; Paul S. (Framingham, MA), Clark; Michael P. (Concord, MA), Bandarage; Upul K. (Lexington, MA), Davies; Ioana (Watertown, MA), Duffy; John P. (Northborough, MA), Gao; Huai (Arlington, MA), Feng; Jun (Acton, MA), Liang; Jianglin (Needham, MA), Kennedy; Joseph M. (Charlestown, MA), Ledeboer; Mark W. (Acton, MA), Ledford; Brian (Norton, MA), Maltais; Francois (Tewksbury, MA), Perola; Emanuele (Brookline, MA)

Assignee: Vertex Pharmaceuticals Incorporated

International Classification: A01N 43/54 (20060101); C07D 239/42 (20060101); C07D 401/04 (20060101)

Expiration Date: 2018-10-28 0:00:00