Patent Number: 8,871,818

Title: Gastrointestinal absorption enhancer mediated by proton-coupled transporter and its preparing method

Abstract: The present invention provides a pharmaceutical preparation that can improve absorption of a pharmaceutical compound in the gastrointestinal tract and that provides, through oral administration or like method, a blood concentration from which sufficient remedial effects can be expected, and a method for producing such a preparation. The invention is directed to a pharmaceutical preparation exhibiting excellent gastrointestinal absorbability comprising a compound recognized by a proton-coupled transporter and a pH-sensitive polymer in an amount sufficient for the gastrointestinal tract to acquire a pH at which the proton-coupled transporter optimally absorbs the compound into a cell.

Inventors: Tsuji; Akira (Kanazawa, JP), Tamai; Ikumi (Kanazawa, JP), Sai; Yoshimichi (Kanazawa, JP), Odomi; Masaaki (Tokushima, JP), Toyobuku; Hidekazu (Tokushima, JP)

Assignee: Otsuka Pharmaceutical Co., Ltd.

International Classification: A61K 47/30 (20060101); A61K 9/14 (20060101); A61K 47/00 (20060101); A61K 38/00 (20060101); A61K 38/55 (20060101)

Expiration Date: 2018-10-28 0:00:00