Patent Number: 8,871,928

Title: Tricyclic compounds, preparation methods, and their uses

Abstract: The present invention relates to novel compounds that inhibit Lp-PLA.sub.2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA.sub.2, for example atherosclerosis, Alzheimer's disease, and/or diabetic macular edema.

Inventors: Wan; Zehong (Shanghai, CN), Zhang; Xiaomin (Shanghai, CN), Tong; Zhaolong (Shanghai, CN), Long; Kai (Shanghai, CN), Dowdell; Sarah E. (Media, PA), Manas; Eric Steven (Lafayette Hill, PA), Goodman; Krista Beaver (Wayne, PA)

Assignee: Glaxo Group Limited

International Classification: C07D 471/00 (20060101); C07D 487/00 (20060101)

Expiration Date: 2018-10-28 0:00:00