Patent Number: 8,877,186

Title: Polypeptides, antibody variable domains and antagonists

Abstract: The invention relates to anti-VEGF polypeptides and antibody single variable domains (dAbs) that are resistant to degradation by a protease, as well as antagonists comprising these. The polypeptides, dAbs and antagonists are useful for pulmonary administration, oral administration, delivery to the lung and delivery to the GI tract of a patient, as well as for treating cancer and inflammatory disease, such as arthritis.

Inventors: Steward; Michael (Stevenage, GB), Pupecka; Malgorzata (Cambridge, GB), Tomlinson; Ian (Stevenage, GB), Enever; Carolyn (Cambridge, GB), Jespers; Laurent (Cambridge, GB), Batuwangala; Thil Dinuk (Cambridge, GB)

Assignee: Domantis Limited

International Classification: C07K 16/22 (20060101); C07K 14/435 (20060101); A61K 39/395 (20060101); C07K 14/475 (20060101)

Expiration Date: 2019-11-04 0:00:00