Patent Number: 8,877,715

Title: Cytotoxic conjugates having neuropeptide Y receptor binding compound

Abstract: There is provided a series of novel neuropeptide Y-cytotoxic conjugates, compositions comprising the same, and methods relating to their therapeutic use for the treatment of disease or condition states associated with aberrant or undesirable proliferation of cells that express NPY-Y1 receptors.

Inventors: Dong; Zheng Xin (Holliston, MA), Zhou; Kevin (Mansfield, MA), Deoliveira; Daniel B. (Bellingham, MA)

Assignee: Ipsen Pharma S.A.S.

International Classification: A61K 38/16 (20060101); A61K 31/41 (20060101); A01N 43/82 (20060101); A61K 31/445 (20060101); A61K 31/44 (20060101); A01N 43/42 (20060101); A61K 31/435 (20060101); A01N 43/40 (20060101); A61K 31/555 (20060101); A01N 55/02 (20060101); A61K 31/33 (20060101); A01N 43/00 (20060101); A61K 31/58 (20060101); A61K 31/56 (20060101); A01N 45/00 (20060101); A61K 31/655 (20060101); A01N 51/00 (20060101); C07K 17/00 (20060101); C07K 16/00 (20060101); C07K 7/00 (20060101); C07K 5/00 (20060101); A61P 35/00 (20060101); A61K 38/00 (20060101); A61K 38/22 (20060101); A61P 3/04 (20060101)

Expiration Date: 2019-11-04 0:00:00