Patent Number: 8,877,732

Title: Combination, kit and method of reducing intraocular pressure

Abstract: The present invention is directed to a combination or a kit comprising a prostaglandin analog and an adenosine receptor A.sub.1 agonist and to a method of reducing intraocular pressure (IOP) in a subject using such combination or kit. In one embodiment, the prostaglandin analog is latanoprost and the adenosine receptor A.sub.1 agonist is Compound A, ((2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrah- ydrofuran-2-yl)methyl nitrate, having the structure, ##STR00001##

Inventors: Kim; Norman N. (Westford, MA), McVicar; William K. (Sudbury, MA), McCauley; Thomas G. (Cambridge, MA), Baumgartner; Rudolf A. (Sudbury, MA)

Assignee: Inotek Pharmaceuticals Corporation

International Classification: A61K 31/70 (20060101); A01N 43/04 (20060101); A01N 37/08 (20060101); A61K 31/235 (20060101); A61K 31/215 (20060101); A61K 31/24 (20060101); A01N 37/10 (20060101); A01N 37/44 (20060101); A01N 37/12 (20060101)

Expiration Date: 2019-11-04 0:00:00