Patent Number: 8,877,744

Title: 1,4-Oxazepines as BACE1 and/or BACE2 inhibitors

Abstract: The present invention relates to 1,4 Oxazepines of formula I ##STR00001## having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease and type 2 diabetes.

Inventors: Narquizian; Robert (Zaessingue, FR), Woltering; Thomas (Freiburg, DE), Wostl; Wolfgang (Grenzach-Wyhlen, DE)

Assignee: Hoffmann-La Roche Inc.

International Classification: A61K 31/553 (20060101); C07D 267/10 (20060101); C07D 413/10 (20060101)

Expiration Date: 2019-11-04 0:00:00