Patent Number: 8,877,796

Title: Spiro-oxindole MDM2 antagonists

Abstract: Provided herein are compounds, compositions, and methods in the field of medicinal chemistry. The compounds and compositions provided herein relate to spiro-oxindoles which function as antagonists of the interaction between p53 and MDM2, and their use as therapeutics for the treatment of cancer and other diseases.

Inventors: Wang; Shaomeng (Saline, MI), Yu; Shanghai (Ann Arbor, MI), Sun; Wei (Yunnan, CN), Kumar; Sanjeev (Ann Arbor, MI), Sun; Duxin (Ann Arbor, MI), Zou; Peng (Ann Arbor, MI), McEachern; Donna (Ann Arbor, MI), Zhao; Yujun (Ann Arbor, MI)

Assignee: The Regents of the University of Michigan

International Classification: C07D 487/10 (20060101); A61K 31/407 (20060101)

Expiration Date: 2019-11-04 0:00:00