Patent Number: 8,877,799

Title: Inorganic salt complexes of vildagliptin

Abstract: The present invention relates to the use of novel vildagliptin complexes for the manufacture of high purity vildagliptin of Formula I and/or pharmaceutical acceptable salts thereof. Further objects of the present invention are pharmaceutically acceptable complexes of vildagliptin and/or amorphous and crystalline forms, anhydrous forms, amorphous and crystalline hydrates, amorphous and crystalline solvates of the complexes and a process for the preparation thereof. Another object of the present invention is the high purity vildagliptin and pharmaceutically acceptable salts thereof prepared form the vildagliptin complexes of the present invention, a process for the preparation thereof and pharmaceutical compositions containing vildagliptin base, pharmaceutically acceptable salts and/or complexes and use thereof for the treatment of type 2 diabetes (NIDDM). The present invention provides pharmaceutically advantageous high purity vildagliptin complexes.

Inventors: Mravik; Andras (Budapest, HU), Koehegyi; Imre (Budapest, HU), Pongo; Laszlo (Kerepes, HU), Volk; Balazs (Budapest, HU), Nemeth; Gabor (Budapest, HU), Barkoczy; Jozsef (Budapest, HU), Nagy; Kalman (Budapest, HU), Ruzsics; Gyoergy (Budapest, HU), Broda; Judit (Budapest, HU), Dancso; Andras (Budapest, HU), Keszthelyi; Adrienn (Budapest, HU), Debreczeni; Jozsef (Budapest, HU)

Assignee: Egis Gyogyszergynar Nyilvanosan Muekoedoe Reszvenytarsasag

International Classification: C07D 207/16 (20060101)

Expiration Date: 2019-11-04 0:00:00