Patent Number: 8,877,815

Title: Substituted carbamoylcycloalkyl acetic acid derivatives as NEP

Abstract: The present invention provides a compound of formula I; ##STR00001## or a pharmaceutically acceptable salt thereof, wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, B, X, m and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides pharmaceutical composition of compounds of the invention, and a combination of pharmacologically active agents and a compound of the invention.

Inventors: Karki; Rajeshri Ganesh (Somerville, MA), Kawanami; Toshio (Boston, MA), Ksander; Gary Michael (Boston, MA), Liu; Qian (Malden, MA), Mogi; Muneto (Waltham, MA), Schiering; Nikolaus (Weil am Rhein, DE), Sun; Robert (Natick, MA)

Assignee: Novartis AG

International Classification: A61K 31/165 (20060101)

Expiration Date: 2019-11-04 0:00:00