Patent Number: 8,877,928

Title: Pegylated cyclopamine analogue, preparation method and uses thereof

Abstract: A PEGylated cyclopamine analog, preparation method, uses thereof and methods for treating proliferative diseases using the same are disclosed. The PEGylated cyclopamine analog is a compound represented by the following formula I, a compound comprising at least one group represented by the following formula I (in formula I, R is straight or branched polyethylene glycol having a molecular weight between 200 and 200,000 Dalton, L and X are linking groups), or their single enantiomers, mixture of enantiomers, mixture of diastereomers, pharmaceutically acceptable salts, solvates, or hydrates. ##STR00001##

Inventors: Song; Chun (Shandong, CN), Zhang; Chengzhi (Beijing, CN), Zhao; Xin (Beijing, CN), Hu; Zhao (Beijing, CN), Xu; Xiuling (Beijing, CN), Zhang; Youzhong (Beijing, CN), Wang; Mingyi (Beijing, CN), Sun; Zhijun (Beijing, CN)

Assignee: Shandong University

International Classification: A61K 31/133 (20060101); C08G 65/333 (20060101); C08L 71/00 (20060101); A61P 35/00 (20060101)

Expiration Date: 2019-11-04 0:00:00