Patent Number: 8,877,947

Title: Process for preparation of substantially pure fosamprenavir calcium and its intermediates

Abstract: The present invention relates to fosamprenavir calcium (Ia) substantially free of isomer impurity, (3R)tetrahydro-3-furanyl(1S,2R)-3-[[(4-aminophenyl)sulfonyl](isobutyl)ami- no]-1-benzyl-2-(phosphonooxy)propyl carbamate (Ib), and its process for preparation thereof. The present invention also provides fosamprenavir calcium intermediate, (S)-3-tetrahydrofuranyl-N-succinimidyl carbonate (IIa) substantially free of (R)-3-tetrahydrofuranylsuccinimidyl carbonate (IIb) and its process for preparation thereof.

Inventors: Arora; Surinder Kumar (Pune, IN), Shabade; Samir Shanteshwar (Pune, IN), Kumar; Gaurav (Pune, IN), Ray; Purna Chandra (Pune, IN), Singh; Girij Pal (Pune, IN)

Assignee: Lupin Limited

International Classification: C07D 307/20 (20060101); C07F 9/06 (20060101)

Expiration Date: 2019-11-04 0:00:00