Patent Number: 8,877,970

Title: Inhibitors of carbonic anhydrase IX

Abstract: Novel radiopharmaceuticals that are useful in diagnostic imaging and therapeutic treatment of disease characterized by over expression of CA-IX comprise a complex that contains a sulfonamide moiety which is capable of binding the active catalytic site of CA-IX, and a radionuclide adapted for radioimaging and/or radiotherapy: ##STR00001##

Inventors: Zimmerman; Craig (Topsfield, MA), Babich; John W. (Cambridge, MA), Joyal; John (Melrose, MA), Lu; Genliang (Winchester, MA), Maresca; Kevin P. (Tewksbury, MA), Barone; Chris (Roxbury Crossing, MA)

Assignee: Molecular Insight Pharmaceuticals, Inc.

International Classification: C07C 311/15 (20060101); A61K 49/00 (20060101); A61K 31/555 (20060101); A61K 51/04 (20060101)

Expiration Date: 2019-11-04 0:00:00