Patent Number: 9,387,239

Title: Meningococcal multivalent native outer membrane vesicle vaccine, methods of making and use thereof

Abstract: The present technology provides vaccine compositions comprising native outer membrane vesicles (NOMVs) from at least one genetically modified strain of Neisseria which provides protective immunity to meningococcal disease, more preferably subtype B meningococcal disease. The present technology further provides methods of immunizing an animal or human against meningococcal disease comprising administering the vaccine composition of the present invention.

Inventors: Zollinger; Wendell David (Silver Spring, MD), Donets; Mikhail (North Potomac, MD), Schmiel; Deborah (Rockville, MD), Ionin; Boris (Potomac, MD), Marques; Ryan (Rockville, MD), Moran; Elizabeth Ellen (Wheaton, MD)

Assignee: U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND

International Classification: A61K 39/095 (20060101); C12N 1/36 (20060101); A61K 39/00 (20060101)

Expiration Date: 2020-07-12 0:00:00